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Thus, inadequate availability of metabolic resources may lead to acute or long-term cognitive impairments (9) and correspondingly, interventions that sustain ATP levels may have application for attenuating cognitive dysfunction in the face of an acute stressor that challenges brain energy metabolism. Cerebral activity is coupled to ATP metabolism, where energy flux is tightly correlated with energy demand (8). Acute deficits in cognitive performance have also been reported in both young adults (6) and children (7) following high-intensity exercise.
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Consistent with this, when oral ATP was administered in the form of non-coated ATP disodium, beneficial effects including reduced fatigue (3), improved strength, power, and body composition (5), and enhanced recovery (6) were observed. However, a recent study demonstrated that ingestion of 400mg uncoated ATP disodium for 15 days prevented decreases in ATP, adenosine diphosphate (ADP), and adenosine monophosphate (AMP) in the bloodstream for up to 30 minutes following high-intensity exercise when compared to placebo (3). Initial studies providing oral enteric coated ATP disodium displayed no apparent efficacy toward enhancing ATP levels, and subsequent research questioned the bioavailability of enteric coated ATP following oral administration (1,2). Oral ATP disodium (adenosine 5'- triphosphate disodium) is a commercially available product available alone and as a constituent in a number of sports supplements that is purported to maintain ATP levels during high-intensity exercise. Study Primary Completion Date: May 2022.Masking: Double (Participant, Investigator).Intervention Model: Crossover Assignment.Placebo on Measures of Mood, Reaction Time and Cognitive Performance” Study Type placebo on anaerobic performance.įull Title of Study: “The Effects of PeakATP (Adenosine 5′ – Triphosphate Disodium) Supplementation vs. To investigate the effect of ATP supplementation versus. placebo on mood, reaction time and cognitive performance before and after an acute bout of fatiguing exercise.
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Acute deficits in cognitive performance have also been reported in both young adults and children following high-intensity exercise however, the effects of supplemental ATP on cognitive performance has not been studied. Oral ATP disodium (adenosine 5'- triphosphate disodium) is a commercially available product available alone and as a constituent in a number of sports supplements that is purported to maintain ATP levels and improve performance during high-intensity exercise.